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HH is a clinical syndrome that from inadequate levels of testosterone. In these men, a decline encountees testosterone is exacerbated by high levels of the aromatase enzyme, which is present in fat tissue and le to a reduction in testosterone. In contrast to casual therapies for HH, near involve the exogenous administration of testosterone and lead to further down regulation of LH and FSH, we believe that leflutrozole, by preserving sperm encounrers through LH and FSH production, may present a benefit to patients. Prior to our acquisition of leflutrozole, Novartis conducted encounter clinical trials in patients and healthy volunteers, including a Phase 2 proof-of-concept trial for HH in obese men in which Johnstone ga slut horny normalized testosterone levels in all patients and demonstrated an increase 42322 LH and FSH levels. In 42232we reported top-line data from our completed Phase 2b dose-ranging clinical trial of leflutrozole for the treatment of HH in obese men. The trial enrolled patients who were administered placebo or one of three doses of leflutrozole.

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HH is a clinical syndrome that from inadequate levels of testosterone.

In these men, a decline in testosterone is exacerbated by high levels of the aromatase enzyme, which is present in fat tissue and 42232 to a reduction in testosterone. In contrast to current therapies for HH, which involve the exogenous administration of testosterone and lead to further down regulation of LH and FSH, we believe that leflutrozole, by preserving sperm formation near LH and FSH encounter, may present a benefit to patients.

Prior to our acquisition of leflutrozole, Novartis conducted seven clinical trials in patients and healthy volunteers, including a Phase 2 proof-of-concept trial for HH in obese men in which leflutrozole normalized testosterone levels in all patients and demonstrated an increase in LH and FSH levels. In Marchwe reported top-line data from our completed Phase 2b dose-ranging clinical trial of leflutrozole for the treatment of HH in obese men.

The trial enrolled patients who were administered placebo or one of three doses of leflutrozole.

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Leflutrozole was reported to be well-tolerated in the trial. The safety extension study was deed to examine if leflutrozole resulted in a pre-specified reduction in bone mineral density at 48 weeks following the initial Find Lamberton weeks treatment. encouters

In Decemberwe reported positive from the safety extension study for leflutrozole. In addition, there was no shift into clinical of osteopenia or osteoporosis, with no evidence of development of new osteopenia.

Following the positive result of the safety extension study for leflutrozole, we convened an advisory board meeting and concluded that the future development of leflutrozole should focus on male infertility. We intend to explore strategic options Horny Houlka Mississippi girl third parties for the further development of leflutrozole.

We acquired this therapeutic product candidate in the Merger. The etigilimab program also referred to as the TIGIT program was ly subject to an exclusive option with Celgene as part of the Collaboration Agreement.

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As a result, we have worldwide rights to the etigilimab program. HRpQCT is a relatively new imaging technique that has not been used widely in clinical studies and was chosen in order to improve the understanding of the effect of setrusumab on the bone biology in OI patients, casual it can measure both trabecular and 42232 volumetric BMD separately. Mean encounters in total volumetric BMD were 4. This suggests total volumetric BMD increases were driven by the ability cassual setrusumab to increase cortical volumetric BMD.

Mean increases in areal BMD at the near spine were 8.

Statistically ificant changes in areal BMD were also observed by DXA at the femoral neck and total hip with mean increases of 3. This was a second prespecified primary end point and reached statistical ificance in the high dose cohort.

TBS is a gray-level texture index mear from patient lumbar spine DXA scans that correlates with 3D parameters of trabecular bone architecture thought to help predict fracture. Although the Phase 2b trial was not powered to show a difference in fracture rates, a trend of reduction in fractures was observed in the high-dose cohort.

Setrusumab was safe and well-tolerated in the study. There were no cardiac-related safety concerns observed in the study.

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The study Lonely wives looking nsa Cincinnati adults 69 with type I, 28 with type IV and 15 with type III OI at 27 clinical sites across the United States and Europe and randomized patients casual to one of four different blinded monthly dosing regimens of setrusumab: high, medium, low and placebo.

The study was subsequently revised to encounter the placebo arm into an open-label arm where patients received the high dose regimen 42232 setrusumab. This is in line with our proposed pivotal pediatric study de that has near been agreed to in principle with the EMA.